METABOLIC ENZYMOLOGY

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Course Description

CMB 703 Metabolic Enzymology (2 credit hours): The online course offers a study of the functional and structural characteristics of metabolic pathway enzymes at the molecular level exploring fundamental protein chemistry that is relevant to understanding enzyme function within those pathways. Using molecular graphics software, students will examine high resolution structures of enzymes and explore changes in structure that occur with classical enzyme mechanisms. Analysis of pre-steady state and steady state enzyme activity as well as enzyme inhibition will be important aspects of the course.

Utilize molecular graphics software to analyze protein structure.
Explain basic geometry, structure, and function of amino acid side chains and prosthetic groups, both in general and within the cellular milieu.
State and recognize the different types of classical enzyme mechanisms.
Describe electron and proton transfer in proteins.
Describe the mechanisms of electron transfer-driven charge separation across membranes.
Analyze pre-steady state and steady state enzyme activity.
Explain the types of reversible enzyme inhibition in metabolic pathways.
Describe several types of methods used to isolate enzymes from cells.
Summarize research literature about an enzyme in a report regarding its chemical and kinetic mechanism of catalysis and enzyme-substrate interactions.
Develop critical thinking skills and analytical skills through data analysis.
Identify interrelatedness between biology and chemistry in biochemistry.

Note: The course topics listed below are for a regular fall or spring semester. The summer semester will be shortened to 10 weeks and several topics will be combined.

Topic	Dates*	Instructor
Non-covalent Bonds in Enzymes	Dates*: Week 1	Instructor: TBD
Enzyme Catalysis	Dates*: Week 2	Instructor: TBD
Electron Transfer	Dates*: Week 3	Instructor: TBD
Redox Reactions	Dates*: Week 4	Instructor: TBD
Basics of Enzyme Kinetics	Dates*: Week 5	Instructor: TBD
Enzyme Inhibition	Dates*: Week 6	Instructor: TBD
Assays of Mitochondrial Complexes	Dates*: Week 7	Instructor: TBD
Electron Transport Chain	Dates*: Week 8	Instructor: TBD
Echinocandins	Dates*: Week 9	Instructor: TBD