ENZYMOLOGY AND CELLULAR METABOLISM

Course Description

CMB 706 Enzymology and Cellular Metabolism (4 credit hours) is a continuation of Biochemistry I. Topics include thermodynamics, pH and acid-base chemistry, metabolism and metabolic regulation including glycolysis, TCA cycle and oxidative phosphorylation. Tissue-specific metabolism studies will include liver metabolism, muscle metabolism, hormonal action and blood clotting. Students will also explore how alteration of these metabolic pathways relates to the development and progression of some human diseases.

Course Information

Explain enzyme function and methods of control of metabolic pathways.
Explain key metabolic pathways and energy balance in specific diseases.
Describe enzymatic reaction mechanisms and signal transduction.
Explain the laws of thermodynamics and their relation to metabolic pathways.
Determine pH, pOH, and pKa of selected solutions.
Describe the homeostatic acid-base balance in the mammalian body.
State the focus of work for biochemists.
Read and critically evaluate the scientific literature.
Interpret and communicate experimental data.
Develop logical steps in a series of experiments.
Explain the relevance and significance of results in selected scientific literature.
Communicate research results effectively through written and oral presentations.
State an ethical issue in the biomedical/molecular life sciences and create a solution.

Note: The course topics listed below are for a regular fall or spring semester. The summer semester will be shortened to 10 weeks and several topics will be combined.

Topic	Dates*	Instructor
1. Enzyme Catalysis: Thermodynamics and Bioenergetics	Dates*: Week 1	Instructor: Hennington
2. Enzyme Kinetics and Regulation	Dates*: Week 2	Instructor: Hennington
3. Bioenergetics in the Cell I	Dates*: Week 3	Instructor: Hennington
4. Bioenergetics in the Cell II	Dates*: Week 4	Instructor: Hennington
5. Oxidative Phosphorylation	Dates*: Week 5	Instructor: Hennington
6. Mitochondria, ROS and Cellular Apoptosis and Disease	Dates*: Week 6	Instructor: Syed
7. DNA Mutation and Repair and Genetic Diseases	Dates*: Week 7	Instructor: Syed
8. Control of Gene Expression	Dates*: Week 8	Instructor: Syed
9. Carbohydrate Metabolism and Hormonal Regulation	Dates*: Week 9	Instructor: Hennington
10. Lipid Metabolism and Hormonal Regulation	Dates*: Week 10	Instructor: Hennington
11. Liver Structure and Function and Metabolic Diseases	Dates*: Week 11	Instructor: Syed
12. Blood Chemistry and Disease Detection	Dates*: Week 12	Instructor: Syed
13. Fibrous Proteins, Skeletal Muscle Structure and Function	Dates*: Week 13	Instructor: Syed